There is at present a unwritten understanding between Israel and Pakistan that the nukes are India centric. Some of the missiles now can reach Israel but Tel Aviv is assured that they do not pose a threat.Honestly if Pakistan does open up relations with Israel.thats fine to be honest. Its geopolitics afterall of course Pakistan should be aware of Israel's intentions.
However this was not always the case. Back in 1970s when Israel became aware she was concerned and this would make logical sense. I can't give you US Supreme Court grade proof and evidence for this but as is always the case in such issues there is not much evidence as the parties don't tend to leave 'fingerprint' around.
But it would be reasonable to surmise that any Israeli PM would have been concerned about a Muslim state which refuses to recognize Israel developing nukes. Thus it is plausible that PM Begin would have been concerned. Furthermore given Israel's very aggressive posture as we saw with the attack on Osirak facility in Iraq in 1980s it would be reasonable to expect Israel to contemplate similar thing to Pakistan in 1980s.
I believe however USA and UK interceded with Israel given that in 1980s the west was involved in the jihad against the Red Army in Afghanistan to which Pakistan was a vital component and Israel was restrained from any rash action that would have been catastrophic to the US effort to defeat Soviet Union. However I believe USA/UK not only interceded but brought about a understanding between Pakistan and Israel which persists to this day.
However Pakistan or Israel will never go public with this.