India Corona thread

VCheng

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A few of the projected costings @VCheng @T-123456 et al:


  • India is said to estimate two injections per person at $2 a shot
  • Another $2-$3 is said to be set aside per individual as infrastructure costs such as storage and transport

$4 for two shots is actually a pretty good deal. Does the transport need refrigeration or dry ice? That can be problematic in warmer countries.
 

Nilgiri

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Does the transport need refrigeration or dry ice? That can be problematic in warmer countries.

I would imagine it needs refrigeration yes... how to make (most) vaccines long term viable at room temperature and resilient overall is ongoing research area:


I would assume findings there cannot be applied so quickly yet to a corona vaccine...since its new research area it looks like.

I would imagine for India the logistics of refrigeration etc are already computed in...but they could definitely be an issue for more remote regions and also for other developing countries.
 

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New Delhi:
Covaxin, the coronavirus vaccine being developed by Bharat Biotech in collaboration with the Indian Council of Medical Research (ICMR), has been cleared for the third phase of clinical trials.

The Hyderabad-based vaccine maker had applied to the Drugs Controller General of India (DCGI) on October 2, seeking its permission to conduct Phase 3 trials for its COVID-19 vaccine candidate.

The firm in its application said that the study would cover 28,500 subjects aged 18 years and above and would be conducted in 19 sites - including Delhi, Mumbai, Patna and Lucknow - across 10 states.

Besides, Bharat Biotech, an indigenously developed vaccine candidate by Zydus Cadila Ltd is also in Phase 2 of human clinical trials.

The Pune-based Serum Institute of India, which has partnered with AstraZeneca for manufacturing the Oxford COVID-19 vaccine candidate, is also conducting Phase 2 and 3 human clinical trials of the candidate in India.

(More at link)
 

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The Serum Institute of India, the world's largest manufacturer of vaccines by volume, will first focus on supplying AstraZeneca Plc's COVID-19 vaccine to Indians before distributing it to other countries, Serum's Chief Executive Adar Poonawalla said on Monday.

"It's very important we take care of our country first, then go on to COVAX after that and then other bilateral deals with countries. So I've kept it in that priority," said Poonawalla, referencing the global COVAX facility, which has been set up to provide COVID-19 vaccines to poorer countries.

The company remains in discussion with the Indian government about inking a purchase agreement for the vaccine, Poonawalla said in an interview with CNBC-TV 18, adding that Serum should have quantities of it ready to sell into India's private market in the first quarter of 2021.

Poonawalla's comments came shortly after AstraZeneca NSE 1.24 % said on Monday its vaccine could be around 90% effective, giving the world's fight against the pandemic a new weapon, cheaper to make, easier to distribute and faster to scale up than rivals.

Serum is hoping the data released earlier on Monday, along with preliminary data from the ongoing trial of the vaccine in India, will allow it to seek emergency use authorisation for the vaccine by year-end, before gaining approval for a full rollout by February or March next year, said Poonawalla.

He said the vaccine in the Indian private market would be priced at 1,000 rupees per dose ($13.50), but that governments signing large supply deals would likely buy it at lower prices.

Poonawalla also said that although Serum has the right to strike direct bilateral deals with more than five dozen nations, on the basis of its licensing deal with AstraZeneca, the company may include the government in some of these discussions.

Poonawalla said the company will be able to produce 400 million doses of AstraZeneca's vaccine by July 2021 and scale up further from there.
 

Indos

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I hope by erly next year mass vaccination have already been conducted every where in the world.
 

Nilgiri

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I hope by erly next year mass vaccination have already been conducted every where in the world.

Depends how early you mean by early.

I dont see majority of ppl vaccinated worldwide well into mid or even late 2021 given the logistics etc.

Definitely though the most vulnerable to covid (elderly and underlying conditions) will be prioritised, barring any serious longer term effects that appear later from the trials done now.

With that prioritisation, the mortality will be stopped largely (and hopefully early 2021 as you say) as rest of population simply can function with herd immunity (given very low mortality rates below 70 years old)...till 2nd and 3rd tier prioritisation schedule comes to them etc. I dont think young kids need vaccine at all if you ask me, the risks might outweigh the benefit for them.

BTW India will play a huge role in all of this, it produces 60% of the worlds vaccines.

Earlier article about this:


I think oxford vaccine will likely be the best one (in total delivery) as its cold chain logistics are the least stringent...and its dosage price also looks very reasonable (quoted right now as low as 3 GBP per shot) Pfizer etc are highly picky+expensive w.r.t that...but let us see.
 

Nilgiri

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will be prioritised

Explanation how this likely will look like for India case:


NEW DELHI: The government has estimated that there are around 3 crore healthcare workers and frontline workers in high risk sectors who will receive the first shot of the Covid-19 vaccine, as and when it becomes available in the country.

This means up to sixty million doses, depending on the dosage regimens of different vaccines, will be reserved for the first group of people who will be vaccinated. Frontline workers will include police personnel, sanitation staff and others.

The second group of people to get priority are the elderly, with special focus on those with co-morbidities. These are estimated to be another 25-27 crore individuals, who could account for another 500-540 million doses.

vaccinedose.jpg


(More at link)
 

Jackdaws

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It's going to be a massive challenge. Modi has also antagonized a lot of state CMs and satraps probably like no PM before him ever has.
 

Nilgiri

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Australian Ambassador to India Barry O’Farrell said that only India can satisfy the world’s demand for Covid-19 vaccines. His comments come after the Indian government took foreign diplomats to vaccine labs for briefing. He said, “There are many vaccines being produced in countries around the world. But there's only one country that has the manufacturing capacity to produce sufficient quantities to satisfy the demand of citizens in every country. And that's India. This is another example of the moment in which India will shine, because of the strength of this sector and the planning that has gone in. I suppose that's not unexpected from a country that itself has suffered so many pandemics in the past.”
 

Nilgiri

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Bit of a tangent, but related in the end to the whole effort we have going on in the modern day too:

@Joe Shearer you ever come across this gentleman and his connection to India?

 

Joe Shearer

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Bit of a tangent, but related in the end to the whole effort we have going on in the modern day too:

@Joe Shearer you ever come across this gentleman and his connection to India?

Of course! The Haffkine Institute is still famous world-wide, surely. This was another factoid leading to the belief in certain Indian academic circles that Jews were the only intellects to be regarded with respect - with great respect akin to reverence - for their acumen. We Bengalis carried it one stage further; the phrase,"Yehudi'r moto phorsha!" is still heard in older circles (Kolkata had a significant Jewish community).
 

Nilgiri

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Serum Institute of India’s CEO Adar Poonawalla spoke on the Covid-19 vaccine production and roll-out. SII, world's largest vaccine maker, is producing Oxford-Astrazeneca vaccine. SII has applied for emergency use license for vaccine in India. Poonawalla said India will get 50% of whatever SII produces. "India is a part of 'COVAX'. We will keep giving 50 per cent of everything we make to India and to COVAX at the same time. India has such a large population that we will probably end up giving the majority of those 50 million doses to India first," Poonawalla said. Watch the full video for more.

 

Jackdaws

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Jackdaws

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The Astra Zeneca / Oxford vaccine will probably be approved in the next few days for rollout in India. Personally, that's the one I'd prefer along with Moderna and Pfizer. Not sure about the Bharat Biotech one.
 

Jackdaws

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A few of the projected costings @VCheng @T-123456 et al:


  • India is said to estimate two injections per person at $2 a shot
  • Another $2-$3 is said to be set aside per individual as infrastructure costs such as storage and transport
From March / April, Serum Institute will no longer supply vaccines just to the Government. A certain % will be available at chemists at about $8 / injection. A significant amout of people will be able to buy them too.
 

Jackdaws

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Here it is - 2 vaccines officially approved -

 

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